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宋智勇
发布时间:2017-10-25

  

宋智勇,男,副教授,理学博士,近年来主要围绕智能化纳米材料的设计与可控制备,用于药物的定点、可控释放,以耐药性细菌为研究对象,开展纳米化学生物学效应研究。目前以第一作者或通讯作者在Nature CommunicationsAdvanced Functional Materials, SmallBiomaterialsChemical engineering journalACSAppliedMaterials &InterfacesEnvironmental Science: NanoChemical Communications等国际学术期刊上发表论文13篇,其中影响因子大于10的论文5篇,大于5的论文9篇。目前主持国家自然科学,华中农业大学校自主创新基金等多项基金。

研究领域

(1)纳米材料的设计与可控制备,用于药物分子的定点、可控释放;

(2)无抗生素纳米载药系统的构建及其针对超级细菌感染治疗;

科研项目

(1)国家自然科学基金委员会,青年项目,21807036,跨血脑屏障CRISPR/Cas13a递送系统的构建及其对狂犬病的治疗研究,2019年01月至2021年12月,27.5万,在研;

(2)华中农业大学自主创新基金,培育专项,2662020LXPY007,细胞膜仿生纳米平台构建及其用于幽门螺旋杆菌靶向治疗研究,2020年05月至2023年4月,21万,在研;

(3)华中农业大学,教师启动基金,纳米材料介导的单克隆抗体细胞内递送及协同抗病毒治疗,2016年09月至2019年8月,15万,结题。

近5年代表性论文

(1)YangWu#,ZhiyongSong#, HuajuanWang, HeyouHan* Endogenous stimulus-powered antibiotic release from nanoreactors for a combination therapy of bacterial infectionsNature communications, 2019, 10 (1), 1-10.

(2)ZhiyongSong#, YangWu#, QiCao, HuajuanWang, XiangruWang, HeyouHan*.pH‐Responsive, Light‐Triggered on‐Demand Antibiotic Release from Functional Metal–Organic Framework for Bacterial Infection Combination Therapy,Advanced Functional Materials, 2018, 28 (23), 1800011.

(3)YangWu, GuiyunDeng, KaiJiang, HuajuanWang,ZhiyongSong*, HeyouHan*. Photothermally triggered nitric oxide nanogenerator targeting type IV pili for precise therapy of bacterial infections,Biomaterials, 2020, 120588.

(4)HuajuanWang#, JinZhang#,ZhiyongSong#, YongliMu, MF Foda, YangWu, HeyouHan.An intelligent platform based on acidity-triggered aggregation of gold nanoparticles for precise photothermal ablation of focal bacterial infection,Chemical Engineering Journal, 2020, 127076.

(5)ZhiyongSong, XiaoyuWang*, GenxinZhu, QinggongNian, HangyuZhou, DongYang, ChenfengQin, RuikangTang*.Virus Capture and Destruction by Label‐Free Graphene Oxide for Detection and Disinfection Applications,Small, 2015, 11 (9-10), 1171-1176.

(6)ShuojunLi#,ZhiyongSong#, CaiyunLiu, XiaolinChen*, HeyouHan*.Biomimetic Mineralization-Based CRISPR/Cas9 Ribonucleoprotein Nanoparticles for Gene Editing,ACS Applied Materials & Interfaces, 2019, 11 (51), 47762-47770

(7)JunMa#,ZhiyongSong#, JianhongYang, YouningWang, HeyouHan*.Cobalt Ferrite Nanozyme for Efficient Symbiotic Nitrogen Fixation via Regulating Reactive Oxygen Metabolism,Environmental Science: Nano, 2020.

(8)ZhiyongSong#, YangWu#, HuajuanWang, HeyouHan*. Synergistic antibacterial effects of curcumin modified silver nanoparticles through ROS-mediated pathways,Materials Science and Engineering: C, 2019, 99, 255-263.

(9)ZhiyongSong, LongLiu, XiaoyuWang, YongqiangDeng, QingongNian, GuanchuanWang, ShunyaZhu, XiaofengLi, HangyuZhou, TaoJiang, XurongXu, RuikangTang*, ChenfengQin*. Intracellular delivery of biomineralized monoclonal antibodies to combat viral infection,Chemical Communications, 2016, 52(9): 1879-1882.

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